Shafir laboratory

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Alexandr Shafir

tenured scientist

Institute of Advanced Chemistry of Catalonia (IQAC-CSIC)
Department of Biological Chemistry
Office: 1224
c/Jordi Girona 20
08034, Barcelona


tel. (+34) 934006100  ext. 1224
alexandr.shafir (at) iqac.csic.es

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HYPERVALENT HALOGEN CHEMISTRY

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OXIDATIVE C-H COUPLING AND HALOGENATIONS

About Alex

Alex Shafir grew up in Kharkov (Ukraine - former USSR). He holds a BA in Chemistry from Hunter College (CUNY, New York) and a PhD in Organometallic Chemistry from UC Berkeley (California), which he carried out under the supervision of John Arnold in the area of ferrocene-based ligands.

· Postdoctoral stay at MIT (USA) in the group of Stephen L. Buchwald working on Cu-catalyzed C-N and C-O coupling

· Ramón y Cajal research fellow at the Autonomous University of Barcelona (UAB)

· 2013-2018: Group Leader at the Institut Català d'Investigación Química (ICIQ, Tarragona)

· Since 2018: Tenured Scientist at the Institute of Advanced Chemistry of Catalonia, IQAC-CSIC·

Selected recent publications

Exploring the benzylic gem-C(sp3)-Boron-Silicon and Boron-Tin Centersas a Synthetic Platform

Wei W. Chen, Nahiane Pipaon Fernández, Marta Díaz Baranda, Anton Cunillera, Laura G. Rodríguez, Alexandr Shafir,* Ana B. Cuenca*

Chem. Sci. 2021, 12, 10514-10521 (link)

Preparation and Synthetic Applicability of Imidazole-Containing Cyclic Iodonium Salts

Nikita S. Antonkin, Yulia A. Vlasenko, Akira Yoshimura, Vladimir I. Smirnov, Tatyana N. Borodina, Viktor V. Zhdankin, Mekhman S. Yusubov, Alexandr Shafir, Pavel S. Postnikov

J. Org. Chem. 2021, 86, 7163-7178 (link)

Iodane‐Guided ortho C−H Allylation

Wei W. Chen, Anton Cunillera, Dandan Chen, Sébastien Lethu,

Albert López de Moragas, Jun Zhu, Miquel Solà,* Ana B. Cuenca,* Alexandr Shafir*

Angew. Chem. Int. Ed. 2020, 59, 20201–20207 (link)

The Power of Iodane‐Guided C−H Coupling:

A Group‐Transfer Strategy in Which a Halogen Works for Its Money

Wei W. Chen, Ana B. Cuenca,* Alexandr Shafir*

Angew. Chem. Int. Ed. 2020, 59, 16294–16309 (link)

Synthesis of Polysubstituted Iodoarenes Enabled by Iterative Iodine-Directed para and ortho C−H Functionalization

Yichen Wu, Sébastien Bouvet, Susana Izquierdo, Alexandr Shafir

Angew. Chem. Int. Ed. 2019, 58, 2617–2621 (link)

The Coming of Age in Iodane-Guided ortho-C−H Propargylation: From Insight to Synthetic Potential

Susana Izquierdo, Sébastien Bouvet, Yichen Wu, Sonia Molina, Alexandr Shafir

Chem. Eur. J. 2018, 24, 15517–15521 (link)

Acid Activation in Phenyliodine Dicarboxylates: Direct Observation, Structures, and Implications

Susana Izquierdo, Stéphanie Essafi, Iker del Rosal, Pietro Vidossich, Roser Pleixats, Gregori Ujaque, Agustí Lledós, Alexandr Shafir

J. Am. Chem. Soc. 2016, 138, 12747–12750 (link)

NH-Heterocyclic Aryliodonium Salts and their Selective Conversion into N1-Aryl-5-iodoimidazoles

Yichen Wu, Susana Izquierdo,Pietro Vidossich, Agustí Lledós, Alexandr Shafir

Angew. Chem. Int. Ed. 2016, 55, 7152–7156 (link)