Shafir laboratory
Alexandr Shafir
tenured scientist
Institute of Advanced Chemistry of Catalonia (IQAC-CSIC)
Department of Biological Chemistry
Office: 1224
c/Jordi Girona 20
08034, Barcelona
tel. (+34) 934006100 ext. 1224
alexandr.shafir (at) iqac.csic.es
HYPERVALENT HALOGEN CHEMISTRY
OXIDATIVE C-H COUPLING AND HALOGENATIONS
About Alex
Alex Shafir grew up in Kharkov (Ukraine - former USSR). He holds a BA in Chemistry from Hunter College (CUNY, New York) and a PhD in Organometallic Chemistry from UC Berkeley (California), which he carried out under the supervision of John Arnold in the area of ferrocene-based ligands.
· Postdoctoral stay at MIT (USA) in the group of Stephen L. Buchwald working on Cu-catalyzed C-N and C-O coupling
· Ramón y Cajal research fellow at the Autonomous University of Barcelona (UAB)
· 2013-2018: Group Leader at the Institut Català d'Investigación Química (ICIQ, Tarragona)
· Since 2018: Tenured Scientist at the Institute of Advanced Chemistry of Catalonia, IQAC-CSIC·
Selected recent publications
Exploring the benzylic gem-C(sp3)-Boron-Silicon and Boron-Tin Centersas a Synthetic Platform
Wei W. Chen, Nahiane Pipaon Fernández, Marta Díaz Baranda, Anton Cunillera, Laura G. Rodríguez, Alexandr Shafir,* Ana B. Cuenca*
Chem. Sci. 2021, 12, 10514-10521 (link)
Preparation and Synthetic Applicability of Imidazole-Containing Cyclic Iodonium Salts
Nikita S. Antonkin, Yulia A. Vlasenko, Akira Yoshimura, Vladimir I. Smirnov, Tatyana N. Borodina, Viktor V. Zhdankin, Mekhman S. Yusubov, Alexandr Shafir, Pavel S. Postnikov
J. Org. Chem. 2021, 86, 7163-7178 (link)
Iodane‐Guided ortho C−H Allylation
Wei W. Chen, Anton Cunillera, Dandan Chen, Sébastien Lethu,
Albert López de Moragas, Jun Zhu, Miquel Solà,* Ana B. Cuenca,* Alexandr Shafir*
Angew. Chem. Int. Ed. 2020, 59, 20201–20207 (link)
The Power of Iodane‐Guided C−H Coupling:
A Group‐Transfer Strategy in Which a Halogen Works for Its Money
Wei W. Chen, Ana B. Cuenca,* Alexandr Shafir*
Angew. Chem. Int. Ed. 2020, 59, 16294–16309 (link)
Synthesis of Polysubstituted Iodoarenes Enabled by Iterative Iodine-Directed para and ortho C−H Functionalization
Yichen Wu, Sébastien Bouvet, Susana Izquierdo, Alexandr Shafir
Angew. Chem. Int. Ed. 2019, 58, 2617–2621 (link)
The Coming of Age in Iodane-Guided ortho-C−H Propargylation: From Insight to Synthetic Potential
Susana Izquierdo, Sébastien Bouvet, Yichen Wu, Sonia Molina, Alexandr Shafir
Chem. Eur. J. 2018, 24, 15517–15521 (link)
Acid Activation in Phenyliodine Dicarboxylates: Direct Observation, Structures, and Implications
Susana Izquierdo, Stéphanie Essafi, Iker del Rosal, Pietro Vidossich, Roser Pleixats, Gregori Ujaque, Agustí Lledós, Alexandr Shafir
J. Am. Chem. Soc. 2016, 138, 12747–12750 (link)
NH-Heterocyclic Aryliodonium Salts and their Selective Conversion into N1-Aryl-5-iodoimidazoles
Yichen Wu, Susana Izquierdo,Pietro Vidossich, Agustí Lledós, Alexandr Shafir
Angew. Chem. Int. Ed. 2016, 55, 7152–7156 (link)